Cookie Policy
Last Updated: 21-Mar-2023
What are cookies?
This Cookie Policy explains what cookies are and how we use them, the types of cookies we use i.e, the information we collect using cookies and how that information is used, and how to manage the cookie settings.
Cookies are small text files that are used to store small pieces of information. They are stored on your device when the website is loaded on your browser. These cookies help us make the website function properly, make it more secure, provide better user experience, and understand how the website performs and to analyze what works and where it needs improvement.
How do we use cookies?
As most of the online services, our website uses first-party and third-party cookies for several purposes. First-party cookies are mostly necessary for the website to function the right way, and they do not collect any of your personally identifiable data.
The third-party cookies used on our website are mainly for understanding how the website performs, how you interact with our website, keeping our services secure, providing advertisements that are relevant to you, and all in all providing you with a better and improved user experience and help speed up your future interactions with our website.
Types of Cookies we use
Manage cookie preferences Cookie Settings You can change your cookie preferences any time by clicking the above button. This will let you revisit the cookie consent banner and change your preferences or withdraw your consent right away.
In addition to this, different browsers provide different methods to block and delete cookies used by websites. You can change the settings of your browser to block/delete the cookies.
Listed below are the links to the support documents on how to manage and delete cookies from the major web browsers.
- Chrome: https://support.google.com/accounts/answer/32050
- Safari: https://support.apple.com/en-in/guide/safari/sfri11471/mac
- Firefox: https://support.mozilla.org/en-US/kb/clear-cookies-and-site-data-firefox?redirectslug=delete-cookies-remove-info-websites-stored&redirectlocale=en-US
- Internet Explorer: https://support.microsoft.com/en-us/topic/how-to-delete-cookie-files-in-internet-explorer-bca9446f-d873-78de-77ba-d42645fa52fc
If you are using any other web browser, please visit your browser’s official support documents.
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Signs & Symptoms.
Here you can find detailed information about the signs and symptoms of Pseudoxanthoma Elasticum, a rare genetic disorder affecting the skin, eyes, and cardiovascular system. Learn about the common symptoms of PXE and how they may progress over time.
Pseudoxanthoma Elasticum. Signs & Symptoms.
PXE causes yellowish thickenings in the flexible areas of the skin, such as the neck, armpit, popliteal, groin and elbow. It looks like a rash as if the neck has not been washed. The skin in these places also slackens. The dermatologist can take a biopsy and have it tested for PXE.
With age, blood vessels calcify. This is accelerated with PXE. The patient may experience pain when walking due to calcification of the veins in the legs. When one stops walking for a while, these complaints disappear; the so-called “shop window legs”. By walking daily, the patient can reduce the complaints; the so-called “gait training”.
A PXE patient also has an increased risk of TIAs and cerebral infarctions due to the calcifications in the blood vessels.
PXE also leads to calcification in the eyes. This can cause cracks under the retina, allowing new blood vessels to grow. Also, the retina at the location of the yellow spot (the location of the central vision) often becomes thin. Both of these often lead to significant vision loss. PXE patients are therefore under the supervision of an ophthalmologist. He can try to prevent visual impairment by administering injections in the eye.
The walls of the blood vessels in the stomach also harden, which increases the risk of stomach bleeding.
The symptoms mentioned earlier do not manifest themselves in most people until around the age of 40. The complaints mentioned are also different for every patient. Some patients have few skin lesions, and others have little or no vision loss. Many patients experience no stomach discomfort, and others have little or no vascular problems. It is also impossible to predict how the disease process will progress.
Is PXE hereditary?
An inherited defect in the ABCC6 gene causes PXE. Dozens of mutations in this gene are now known that can cause the disease. PXE is a recessive disease, meaning there must be two errors in the genetic material to get the disease. Therefore, children of PXE patients are usually only carriers and can only have the disease if their father or mother, who does not have PXE, is also a carrier. The chance of this is 25%.
PXE & Pregnancy.
Women with PXE can generally have normal pregnancies. There are also no known complications or effects on the fetus.
If a woman with PXE wants to become pregnant, she must inform the doctors treating her. When giving birth, there is a risk of bleeding in the eye during pushing, but with good guidance, this does not have to be a problem.
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